A circRNA-derived IRES-like element enables programmable translational activation of the endogenous chaperone HSP90
SynFarsa is characterized, a synthetic circRNA-derived IRES-like element that promotes cap-independent translation in mouse and human cells and provides a circRNA-derived effector domain for targeted translational upregulation of an endogenous protein.
Guy Aoun, Andrea Vandelli, Riccardo Delli Ponti et al.
· bioRxiv · 0 citations