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Author

Rick Li

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#gene editing Open access Sep 2026

Human genetics implicates a BACH2-NRF2 axis in fetal haemoglobin activation.

Human genetic studies have identified key regulators of fetal haemoglobin (HbF) expression, including BCL11A, resulting in therapeutic advances1-8. Yet the mechanisms by which HbF expression is activated remain incompletely understood9. Here we conduct a large multi-ancestry genome-wide association study of HbF levels...

Chun-Jie Guo, U. Arora, Xiao-Heng Cheng et al. · 0 citations
Open access Aug 2026

Orthoflaviviruses use diverse binding modes to engage LDLR family receptors

Cryo-electron microscopy structures of yellow fever virus (YFV) E bound to low-density lipoprotein receptor-related protein 4 (LRP4) and LRP8, and of tick-borne encephalitis virus (TBEV) E bound to LRP8 are determined, identifying key determinants of receptor specificity for these two orthoflaviviruses.

Chenggong Ji, Laurentia V. Tjang, Biswajit Das et al. · 0 citations

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