Author

Rifaat Safadi

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Open access Aug 2026

Mitochondrial NCLX couples glucagon- and PDE2A-Dependent signals to regulate hepatic lipid metabolism

Mitochondrial calcium signaling, particularly its glucagon-mediated oscillatory dynamics, plays a pivotal role in regulating hepatic metabolism and is known to be disrupted in steatotic liver disease. We recently identified the mitochondrial Na+/Ca2+exchanger NCLX as a key mediator of glucagon-induced mitochondrial cal...

Essam A. Assali, Mahmoud Taha, Ahmad Salhab et al. · Molecular Metabolism · 1 citation

#protein folding Open access Oct 2026

Epigallocatechin-3-Gallate Restores the Pulmonary Keap1-Nrf2-HO-1 Pathway and Attenuates Bile Acid-Associated Lung Injury in a Mouse Model of MASH

The crosstalk between the liver and the lung is complex and not yet fully understood; however, recent studies suggest that metabolic dysfunction, often originating in the liver, can influence lung injury and other lung diseases. The current study investigates the role of bile acids (BA) in mediating lung injury in a mo...

Ahmad Salhab, Johnny Amer, Rifaat Safadi · International Journal of Mol... · 0 citations