Author

Rob M. Scrutton

3 papers indexed here

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Open access Sep 2026

Mapping high resolution, multidimensional phase diagrams of near-physiological protein condensates

Biomolecular condensates are membraneless compartments, crucial for organising and regulating diverse cellular processes. Current approaches to study condensate biology either use simplified recombinant protein systems with limited physiological relevance, or complex live-cell models with restricted experimental cont...

Tanushree Agarwal, Tomas Šneideris, Fabian Svara et al. · Nature Communications · 0 citations

#protein folding Open access Sep 2026

Mechanistic Interpretability of Protein Language Models Reveals Encoded Structural and Functional Properties of Intrinsically Disordered Proteins

It is shown that ESM-2 exhibits reduced attention on disordered regions, yet still encodes meaningful biological signals, and that both the radius of gyration and individual dynamic contact maps, key characteristics of IDPs, can be obtained from the model logits and embeddings.

Lauren Naworski, Lydia L. Good, Rob M. Scrutton et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

Quantifying molecular specificity in excipient-driven antibody solubilization

It is shown that excipient-mediated solubilization of therapeutic antibodies is markedly molecularly specific, and the integration of high-throughput experimentation with molecular feature analysis offers a foundation for improving the understanding and prediction of antibody-specific formulation behavior.

Zexiang Han, Nadia A. Erkamp, Rob M. Scrutton et al. · mAbs · 0 citations