Female iPSC X chromosome inactivation erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation.
Variable XCI is found in CRISPR-edited female iPSCs, which was largely preserved in iPSC-derived neurons and predominantly influenced X-linked genes, which has significant implications in hiPSC-based modeling of neurodevelopmental disorders.
Christina Thapa, Emily K. Oh, David Sirkin et al.
· Stem Cell Reports · 0 citations