Author

Rui-An Wang

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Open access Aug 2026

Single-cell and spatial transcriptomic profiling identifies a fibroblast-like endothelial state and the MDK-NCL signaling axis in prostate cancer microenvironment remodeling

Highlights • Single-cell analysis identified a fibroblast-like endothelial state in prostate cancer.• The MDK-NCL axis marked active tumor microenvironment communication.• FLE enrichment was associated with stromal remodeling and poor prognosis.• The FLE-related signature stratified patient risk across three independen...

Rui-An Wang, Yi-Fan Li, Xiaoxiang Wang · Translational Oncology · 0 citations

Review Open access Aug 2026

Single-cell and spatial omics of metabolic-immune ecosystems in prostate cancer: from androgen signaling to therapy resistance

This review synthesizes single-cell and spatial omics evidence for metabolic-immune ecosystems in prostate cancer, emphasizing the transition from androgen dependence to castration resistance, lineage plasticity, metastatic niche adaptation, and therapy resistance.

Rui-An Wang, Yi-Fan Li, Xiaoxiang Wang · Frontiers in Immunology · 1 citation