Author

Rui Chen

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Open access Aug 2026

Adaptive and degenerative mitochondrial remodeling define distinct redox states in age-related macular degeneration

Age-related macular degeneration (AMD) is associated with mitochondrial dysfunction and oxidative stress, yet the relationship between mitochondrial remodeling, redox homeostasis, and disease progression remains poorly understood. Nonhuman primates (NHPs) develop spontaneous AMD-related phenotypes, including punctate d...

Cecilia Giulivi, Carol Villafuerte-Trisolini, Z. Greenblatt et al. · Redox Biology · 0 citations

Open access Sep 2026

Aberrant phase separation from a rare ABI3 mutation drives microglial dysfunction and Alzheimer's risk

Although the ABI3 S209F variant is a recognized genetic risk for Alzheimer's disease (AD), its pathogenic mechanism remains elusive.

Sheng-Nan Li, Jiong-Tong Lu, Kai-Xing Zeng et al. · Alzheimer's & Dementia · 0 citations

Open access Jul 2026

Metabolic reprogramming via SIRT2-deficient microglial large extracellular vesicles ameliorates alzheimer's pathology.

LEVs are identified as a critical vesicle subtype mediating the effects of SIRT2 knockdown and support a cell-free therapeutic strategy for AD centered on EVs-driven metabolic reprogramming of microglia.

Xiaolu Tang, Rui Chen, Jiawei Xing et al. · Journal of Neuroinflammation · 0 citations