Aug 2026
DHCR24+ tumor epithelial cells drive cisplatin resistance in bladder cancer by enhancing cholesterol metabolism to activate lipid raft-associated MAPK signaling
This study characterizes a specific DHCR24+ tumor epithelial subpopulation that orchestrates cisplatin resistance via the "cholesterol-lipid raft-MAPK" axis and establishes a clear mechanistic link between cholesterol metabolism and cisplatin sensitivity.
Yuan-Qiao Zhao, Zhuo Xing, Meng-Meng Wang et al.
· Oncogene · 0 citations