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DHCR24+ tumor epithelial cells drive cisplatin resistance in bladder cancer by enhancing cholesterol metabolism to activate lipid raft-associated MAPK signaling

Yuan-Qiao Zhao Zhuo Xing Meng-Meng Wang L. Fu Rui-Lin Liu Ze-Xian Ding Yuan Li Yin-Huai Wang B. Yan Xue-Qiang Zhu
Aug 2026 · Oncogene · Vol 45, pp. 4454 - 4470 · 0 citations · 66 references
Medicine

TL;DR

This study characterizes a specific DHCR24+ tumor epithelial subpopulation that orchestrates cisplatin resistance via the "cholesterol-lipid raft-MAPK" axis and establishes a clear mechanistic link between cholesterol metabolism and cisplatin sensitivity.

DOI PubMed Semantic Scholar
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