Compared with traditional drugs targeting penicillin-binding proteins (Pbps), targeting the upstream coordinators of bacterial peptidoglycan (PG) synthesis is a highly promising strategy for overcoming the frequent occurrence of resistance to β-lactam drugs. Eukaryotic-like serine/threonine kinases (eSTKs) are core coo...
Porcine reproductive and respiratory syndrome virus (PRRSV) has the characteristics of a fast evolution rate and high genetic heterogeneity. PRRSV-1 and PRRSV-2 are co-circulating, and the threat they pose to the health of pigs worldwide continues to rise. In this study, two PRRSV strains with significantly different g...
Jia-Kai Li, Shuo Li, Jie Han et al.· Viruses· 0 citations
This study identified potent AMPs with promising therapeutic potential by constructing and screening a synthetic random peptide library using a bacterial surface display system, and identified WP-4 and WP-6, which showed high antimicrobial activity, good biocompatibility, rapid bactericidal effects, and low propensity...
Shuai-Yang Wang, Shuang Wang, Xiu-Jian Liu et al.· Journal of Medicinal Chemist...· 0 citations
The potential of AI-assisted de novo protein design for generating effective Stx-neutralizing proteins is demonstrated and a promising framework for the development of novel therapeutics is established.
Xiang-Lin Zhao, Xiao-Tang Feng, Huai-Xia Li et al.· Journal of Agricultural and...· 0 citations
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