Author

Ruo-Qing Jia

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Open access Aug 2026

SILCS-Guided Feature Encoding Expands Ligand Recognition at an HBV Core Protein Interface

Hepatitis B virus (HBV) infection depends on coordinated capsid assembly and virion production. A hydrophobic pocket at the intradimer interface of the HBV core protein has been linked to secretion phenotypes and shown to bind small molecules, but its interaction landscape remains poorly defined. Here, we combine atomi...

Zixing Fan, Ruo-Qing Jia, Diane L. Lynch et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

De novo design of protein antagonists of bacterial pathogen type III secretion system needle assembly

The rational design and characterization of functional T3SS needle binding proteins are reported, establishing a molecular blueprint for the design of functional T3SS needle binding proteins, enabling future efforts to disrupt conserved secretion systems underlying bacterial pathogenesis.

Ruo-Qing Jia, Jin-Kyo Jung, Aashi Inani et al. · Scientific Reports · 0 citations