Aug 2026
Dual epithelial-mesenchymal induction of Sfrp1/Frzb constrains alveolar epithelial differentiation in neonatal hyperoxia-induced lung injury.
A fibroblast-dominated Sfrp1/Frzb-mediated niche is identified that constrains AT2 differentiation into AT1 cells, providing a cellular basis for impaired alveolar regeneration in BPD and suggesting potential therapeutic targets.
Ming Xu, Liyan Xiang, Gongxia Ling et al.
· American Journal of Respirat... · 0 citations