Dual epithelial-mesenchymal induction of Sfrp1/Frzb constrains alveolar epithelial differentiation in neonatal hyperoxia-induced lung injury.

Glutaminase regulates alveolar regeneration through autophagy-YAP/TAZ in pulmonary fibrosis.

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

ABSTRACT Alveolar type 2 (AT2) cells, which originate from bud tip progenitors during lung development, maintain pulmonary homeostasis through surfactant secretion and regenerative capacity, yet their plasticity has been challenging to model in vitro, limiting their applications in disease modeling and regenerative the...

Betaine restores OPA1-mediated mitochondrial fusion in alveolar epithelial type 2 cells and ameliorates hyperoxic lung injury in newborn mice

Bronchopulmonary dysplasia (BPD) is a common chronic respiratory disease in preterm infants, characterized by impaired lung development. Mitochondrial dysfunction of alveolar type II epithelial (AT2) cells plays a critical role in the pathogenesis of BPD. Betaine is an endogenous methyl donor with anti-inflammatory...

Apoptosis inhibition reprograms alveolar myofibroblasts toward ductal myofibroblasts.

The epithelial tree of the lung is shaped proximo-distally by airway smooth muscle cells (ASMCs), ductal myofibroblasts (DMFs), and, transiently, alveolar myofibroblasts (AMFs). Lineage tracing and snapshot imaging suggest the clearance of AMFs via apoptosis post-alveologenesis, although definitive evidence is lacking....

IPF distal lung epithelial cells acquire a DNA methylation signature consistent with activation of basal cell transcriptional programs

High-resolution DNA methylation profiling of purified distal lung epithelial cells from 10 age-matched control and 14 IPF lungs identified widespread methylome remodeling in the IPF lung epithelium, potentially providing future therapeutic strategies by identifying putative regulatory elements associated with aberrant...

Wnt signaling decline drives age-related alveolar stem cell loss and impairs lung repair