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S. Caoili

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Open access Jul 2026

A Procoagulant Peptide Analog of the SARS-CoV-2 Nucleocapsid C-terminal Domain

The results support a model in which N389 functions as a stable, charge-based scaffold that coordinates divalent cations and/or directly nucleates fibrin(ogen), while highlighting limitations of bulk clotting assays and the need for targeted thrombin generation, binding, aggregation, and contact-activation studies.

B. Pollo, F. M. Climacosa, S. Caoili · 0 citations