The results support a model in which N389 functions as a stable, charge-based scaffold that coordinates divalent cations and/or directly nucleates fibrin(ogen), while highlighting limitations of bulk clotting assays and the need for targeted thrombin generation, binding, aggregation, and contact-activation studies.
3D models of the C-terminal SC region suggest that the major C-terminal domain of SC folds into a single-layer β-sheet structurally similar to the membrane occupation and recognition nexus (MORN) family of tandem repeats, which is critical for understanding SC-mediated fibrin generation.
Pablo Fuentes-Prior, A. Maddur, Peter Panizzi et al.· Biological chemistry· 0 citations
The molecular mechanism of human A4GALT is revealed at atomic detail using QM/MM simulations, revealing a conformational rearrangement involving a 310-helix that stabilizes the donor substrate and promotes a front-face SNi-like catalytic mechanism, in which a short-lived oxocarbenium-ion intermediate forms.
Nicky de Koster, Òscar Vidal-Gironès, Rowan de Graaf et al.· Angewandte Chemie· 0 citations
Findings from a proof-of-concept, expanded access trial for COVID-19 patients prove the acellular biologic is safe and potentiallyective to prevent disease progression in a high-risk COVID-19 population with mild-to-moderate symptoms.
M. Bellio, Cassie Bennett, A. Arango et al.· 0 citations
In silico ADME analysis indicated that both lead compounds possess favourable drug-like properties, with no Lipinski's rule-of-five violations, balanced lipophilicity, and acceptable predicted oral absorption, supporting their pharmacokinetic potential.
Dinesh Krishna Narukulla, Shrilekha Chilvery, C. Godugu et al.· Bioorganic & Medicinal Chemi...· 0 citations
Results show that amantadine interactions with simplified SARS-CoV-2 lipid envelopes depend on both the net charge of the lipid headgroup and the membrane organization, which is influenced by the presence or absence of unsaturated alkyl chains in the hydrophobic region.
M. Mierzejewska, Izabella Leszczyńska, Gabriela Węsierska et al.· RSC Advances· 0 citations
The first evidence for the expression levels and subcellular localization of apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1), evaluated alongside cytosolic and mitochondrial markers, in resting human PLTs isolated from a cohort of healthy donors is provided.
Isabella Parolini, Alessia Bellina, G. Carpi et al.· The FASEB Journal· 0 citations
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