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S. Despa

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Review Jul 2026

The PERK paradox in aging: how ER stress shapes senescence and neurodegeneration.

Evidence is synthesized that ER stress is not merely a correlation of aging but a mechanistic contributor to age-related decline, with senescence emerging as a major downstream fate in multiple tissues and therapeutic opportunities and open questions centered on restoring adaptive PERK/ISR dynamics to support healthy a...

Vivek K Pandey, R. Sachdeva, S. Despa · 0 citations

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