Evidence is synthesized that ER stress is not merely a correlation of aging but a mechanistic contributor to age-related decline, with senescence emerging as a major downstream fate in multiple tissues and therapeutic opportunities and open questions centered on restoring adaptive PERK/ISR dynamics to support healthy aging are discussed.
This review synthesizes current research on how intracellular C3 (intC3), and intracellular C5 (intC5) in certain contexts engage in extensive crosstalk with the mTOR, NF-κB, and AMPK pathways to modulate core cellular processes to modulate age-related diseases.
Naheemat Modupeola Gold, M. N. Okeke, Samuel Ewhea Ajoronor et al.· Ageing Research Reviews· 0 citations
SUMOylation is a reversible post-translational modification increasingly recognized for its role in coordinating cellular responses to metabolic stress during aging. Emerging evidence indicates that it functions beyond a conventional modification, representing an adaptive stress‑responsive regulatory network that integ...
Xin-Yue Liu, Shuang Chen, Dong-Can Liu et al.· Ageing Research Reviews· 0 citations
Overall, aging outcomes reflect a dynamic equilibrium between damage and repair processes, and how this balance is modulated in long-lived individuals may inform strategies to promote healthy aging and delay the onset of age-related diseases.
S. Sideri, M. Cosentino, Laura Forcina et al.· Mechanisms of Ageing and Dev...· 0 citations
Cellular senescence is a stress-response program that coordinates cell-autonomous growth arrest and non-cell autonomous remodeling of the tissue environment. Initially defined through its role in aging and tumor suppression, senescence is now recognized as a highly complex program shaped by cell-intrinsic and environme...
Efi Tsouri, Niovi Athanasopoulou, L. Akkari et al.· Seminars in Immunology· 0 citations
How cells balance this tightrope between adaptation and cell death in the context of cancer is dissected, and how UPR signaling drives angiogenesis, metastasis, immune-evasion, and chemoresistance is explored before finally discussing its therapeutic potential.
