Author

S. Dutta

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Open access Oct 2026

A voltage-gated porin PPE1 regulates secretion and drug resistance in Mycobacterium tuberculosis.

Drug resistance in Mycobacterium tuberculosis (Mtb) remains a formidable clinical hurdle, compounded by the fact that the pathways by which antibiotics penetrate its multilayered cell envelope remain incompletely mapped. We identify PPE1 as a voltage-gated outer-membrane porin that mediates the secretion of kupyaphores...

Mohit Yadav, Neilah Firzan C. A, D. Mandal et al. · Proceedings of the National... · 0 citations

#protein folding Open access Oct 2026

Cryo-EM reveals the quaternary architecture of TenpIN type III toxin-antitoxin RNP complex common to pathogenic bacteria.

Type III toxin-antitoxin (TA) systems are anti-phage defense systems in bacteria that comprises a protein toxin and a cognate non-coding RNA antitoxin. Under normal conditions, the antitoxin binds and inhibits the toxin. Upon phage infection, antitoxin is neutralized, releasing the active toxin, which cleaves the bacte...

Kavya Nadig, S. Padmanaban, Salik Noor et al. · PLoS Pathogens · 0 citations

Aug 2026

Molecular insights into inhibitor action on the catalytic activity of Mycobacterium tuberculosis cystathionine β-synthase enzyme.

These findings provide a mechanistic rationale for MtbCBS inhibition, and the unexplored roles of these key residues can be considered in the design of next-generation inhibitors targeting CBS enzymes implicated in infectious diseases, cancer, and neurological disorders.

Sainath Polepalli, Anupam Roy, Bapan Mondal et al. · International Journal of Bio... · 0 citations