Aug 2026
Locus-specific transposable element expression drives human hematopoietic stem cell disease pathophysiology
This study provides direct evidence that VEXAS-specific TE govern HSC clonal dominance, thereby uncovering a regulatory axis underlying HSC biology and disease mechanisms, opening a therapeutic strategy directed towards the repetitive genome.
A. Varesi, Sontago Dong, Chiara Gaddoni et al.
· bioRxiv · 0 citations