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Locus-specific transposable element expression drives human hematopoietic stem cell disease pathophysiology

A. Varesi Sontago Dong Chiara Gaddoni Kerstin B. Kaufmann T. Wong I. Merelli Andy G. X. Zeng Jessica McLeod Liqing Jin Isabella di Biasio I. Novitzky-Basso J. Mattson Stephanie Z. Xie Bo-Wen Li S. Ferrari John E. Dick
Aug 2026 · bioRxiv · 0 citations
Biology

TL;DR

This study provides direct evidence that VEXAS-specific TE govern HSC clonal dominance, thereby uncovering a regulatory axis underlying HSC biology and disease mechanisms, opening a therapeutic strategy directed towards the repetitive genome.

DOI Semantic Scholar
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