Author

S. Giannelli

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Open access Sep 2026

Targeted AAV gene therapy for neuroblastoma via direct capsid-antibody coupling.

Adeno-associated viral (AAV) vectors are widely used in gene therapy for their versatility and safety, but their broad tropism limits cell-specific applications such as targeting primary or metastatic tumor cells. To address this, we developed AAV-STITCH, a strategy using SpyTag technology to covalently attach polypept...

Mirko Luoni, Stefano Parracino, S. Giannelli et al. · EMBO Molecular Medicine · 0 citations

#gene editing Open access Sep 2026

Targeting white matter astrocytes with a Gfap-disruptive Cas9 nuclease benefits a murine model of Alexander disease.

Astrocytes are intriguing therapeutic targets due to their crucial role in initiating and promoting demyelination in the central nervous system. By efficient on-target editing, we can permanently disrupt detrimental genes and restore normal physiological processes. Here, we have optimized an AAV platform to deliver the...

Anne E. J. Hillen, I. Capuano, Barbara Gega et al. · Molecular Therapy · 0 citations