Open access
Sep 2026
Structural and genetic dissection of RNA-guided gene repression by TnpB-derived transcription factors
TnpB nucleases, the evolutionary progenitors of CRISPR-associated Cas12 enzymes, are transposon-encoded, RNA-guided endonucleases found throughout bacteria. Independent of the trajectory towards adaptive immunity, TnpB nucleases have also recurrently given rise to TnpB-like nuclease-dead repressors (TldRs), a family of...
R. Xiao, Americo A. Casas-Ciniglio, Ho-Ang C. Le et al.
· bioRxiv · 0 citations