ABSTRACT Pseudomonas aeruginosa is a versatile, opportunistic pathogen, well-known for its adaptability to the challenging conditions encountered during infection of the human host. In chronic biofilm-associated infections, variations in motility and LPS structure are commonly observed adaptive traits. In this study, w...
Oliver Hartmann, Matthias Preusse, Ann Kathrin Heroven et al.· mBio· 0 citations
The resurgence of phage therapy has renewed interest in the interplay between phage resistance and antibiotic susceptibility1,2,3 and has stimulated research in the emergent field of non-canonical cellular functions carried out by defence systems4. Yet it remains largely unknown whether intracellular antiphage defence...
Maureen Micaletto, N. O. Gomez, A. Olina et al.· bioRxiv· 0 citations
The ribosome–mRNA interface is identified as an intracellular determinant of antibacterial PNA susceptibility and rpsLI82N alters uS12-dependent 30S assembly and initiation-complex dynamics, thereby changing the effective occupancy of mRNA translation-initiation regions.
J. Frimodt-Møller, I. M. Roman, Thomas Prossliner et al.· bioRxiv· 0 citations
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