S. M. Gomha

Synthesis, characterization, and evaluation of novel diphenylpyrazole-based hydrazine-1-carboximidamides as broad-spectrum antibacterial leads with antibiofilm and virulence-modulating activities

The emergence of multidrug-resistant bacterial pathogens and biofilm-associated infections highlights the urgent need for antibacterial agents with novel chemical architectures and complementary modes of action. In the present study, a new series of diphenylpyrazole-based hydrazine-1-carboximidamide derivatives (5a–i)...

One Electrifying Decade of Organic Syntheses: A Literature Survey Based on Different Electrode Combinations

Synthetic organic chemistry offers an endless scope in various domains of science, and electro-organic synthesis has grown as a green alternative to synthetic organic chemistry, obviating the necessity for harmful oxidants and reductants. Electro-organic reactions have attracted considerable attention globally in both...

Interrogating imidazo[2,1-b]thiazole-4-thiazolidinone hybrids as antidiabetic leads: molecular cartography, pharmacokinetic profiling and rodent therapeutic response.

Diabetes mellitus remains a major global health challenge, necessitating the development of new therapeutic agents targeting key enzymes involved in carbohydrate metabolism. In this study, ten novel imidazo-thiazole-thiazolidinone hybrids were designed, synthesized and their structural integrity was confirmed through 1...

Synthesis, antitumor evaluation, and in silico investigation of pyridine-based pyrimidotriazine and triazolopyrimidine derivatives as potential EGFR-targeted anticancer agents

Cancer remains a major global health challenge and one of the leading causes of mortality worldwide. In the present study, a new series of fused nitrogen-containing heterocyclic derivatives was synthesized from a pyridine-based pyrimidinethione key synthon. Hydrazinolysis followed by cyclo-condensation and condensation...

Computer-aided development of novel thiazolidinone–thiazole derivatives: multidimensional structure–activity relationships revealed by quantum chemical analysis, molecular docking and biological investigation

Computer-aided molecular engineering of novel imidazolone–chalcone conjugates as antidiabetic agent: synthesis, molecular docking, DFT study, enzyme kinetics and ADME profiling

Recent Advances in the Synthesis of Quinazoline Derivatives

Quinazoline is a privileged nitrogen-containing heterocyclic scaffold of considerable importance in medicinal and pharmaceutical chemistry. This review critically summarizes representative synthetic approaches to quinazoline derivatives, covering foundational reports through studies published up to 2025. The litera...

Water-Driven Multicomponent Reactions: A Sustainable Platform for Heterocycle Synthesis

Quinazoline-tethered thiazolo[3,2-a]pyrimidines and their cyclic chalcone derivatives as HIV-1 reverse transcriptase inhibitors: green synthesis, molecular docking, and in silico studies

Nitrogen-fused heterocycles have attracted considerable research interest in pharmaceutical, medicinal, organometallic, and materials chemistry. In this work, two new series of quinazoline-linked thiazolo[3,2-a]pyrimidines and their cyclic chalcone derivatives were synthesized using choline hydroxide as an environmenta...

Indium Phosphide Quantum Dots for Near‐Infrared Luminescence‐Based Bioimaging and Theranostics: From Photophysical Design to Clinical Translation

Indium phosphide (InP) quantum dots (QDs) have emerged as promising cadmium‐free luminescent nanomaterials for near‐infrared (NIR) bioimaging and theranostic applications owing to their tunable optical properties, photostability, and improved biocompatibility. This review highlights recent advances in the photophysical...

Unraveling Dynamic Disorder in Metal Halide Perovskite Quantum Dots: Atomistic Insights Into Structure–Carrier Coupling From Ab Initio and Nonadiabatic Simulations

Metal–halide perovskite quantum dots (PQDs) have emerged as highly dynamic nanoscale semiconductors whose optoelectronic properties are governed by a complex interplay of lattice fluctuations, electronic excitation processes, and surface‐mediated interactions. This review provides a comprehensive atomistic perspectiv...

Synthesis, spectroscopic and DFT investigation of a dual-fluorophore methylene blue-naphthalimide probe for selective Cu2+ ions sensing and HeLa cell imaging.

A new fluorescent probe based on fluorophores methylene blue and 1,8-naphthalimide is designed, synthesized, and utilized for the specific detection of Cu2+ ions in physiological conditions demonstrating that MB-M is a promising fluorescent probe for Cu2+ ions ion detection.