TL;DR
It is suggested that the synthesized pyridine scaffolds hold potential as lead candidates for further antiviral drug development.
A novel and an efficient synthesis of a series of cyano-amide derivatives 3a-h was achieved via solvent-free reaction of benzylcyanide derivatives 1 with isocyanate derivatives 2 at room temperature. The produced components were structurally characterized by NMR spectroscopy multinuclear: 1 H and 13 C and e...
A sustainable and environmentally friendly approach for the synthesis of novel pyrimidine Schiff base derivatives through a multicomponent grinding reaction conducted at room temperature under solvent-free conditions is reported, suggesting that compound (3) may serve as a promising lead candidate for breast cancer the...
The design and synthesis of ten disubstituted tetrazole derivatives (5a–5j) via a one-pot, four-component Ugi-azide reaction (UGI-4CR) employing 2-(4-chloro-2-formylphenoxy)acetonitrile, variously substituted primary aromatic amines, trimethylsilyl azide, and tert-butyl isocyanide in anhydrous methanol at ambient tempe...
Abstract This study focuses on the design, green synthesis, and biological evaluation of a series of novel pyrano-bis-coumarin analogs as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. A new saccharin-based ionic liquid, tris(2-hydroxyethyl)ammonium 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)...
The weakly coordinating ketone group-directed C–H functionalizations of chromones, flavones, 1,4-naphthoquinones, (thio)xanthones, and acridones with ethenesulfonyl fluoride under rhodium(III) or ruthenium(II) catalysis are described. These protocols efficiently provide a range of chromone-based scaffolds and xanthone...
The findings suggest adamantane as a feasible backbone to develop anticancer agents which may act in-part via CDC25A interaction, suggest adamantane as a feasible backbone to develop anticancer agents which may act in-part via CDC25A.
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