Author

S. Macias

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#gene editing Open access Sep 2026

Universal donor plasmids for biallelic degron-tagging in mammalian cells and organoids

A series of universal donor vectors are generated to enable biallelic integration of different degron tags using different selection strategies (FACS, drug selection) and can be fused in-frame to endogenous protein C-termini via homology-independent repair following Cas9-induced double strand breaks.

S. Ö. Pohl, Brianda Hernandez Moran, Camila Guzman Cardozo et al. · bioRxiv · 0 citations

Open access Jul 2026

DICER1-related tumour predisposition mutations increase 3p-miRNA function and HERVH activity

The DICER1 gene is mutated in cancer, including in DICER1-related tumour predisposition. Cancer-associated hotspot mutations have been reported in both catalytic domains of DICER and are predicted to disrupt miRNA biogenesis. To understand how these hotspot mutations contribute to cancer development, we generate cell l...

K. Gordon, N. Bellora, Jeroen Witteveldt et al. · Nature Communications · 0 citations