Minimal cells offer a platform to uncover the fundamental physicochemical principles of cellular life. While genomes, proteomes, and metabolic networks of cells have been elucidated, the lipidome, which determines the physicochemical identity of the membrane, remains only partially characterized. Yet, the membrane is a...
Caterina Presutti, Mert Bozoflu, Joanna Juhaniewicz-Dębińska et al.· Nature Communications· 1 citation
It is shown that Ceg14 is selectively activated by G-actin and the cryo-EM structure of the Ceg14-actin-AnkJ complex is determined, which shows that actin and AnkJ reciprocally remodel its multipart catalytic center to determine its catalytic state and reaction output.
D. Shatskiy, Marloes S. Eerelman, S. Marrink et al.· bioRxiv· 0 citations
A new software package, Fast-Forward, which aids parametrization of models for the widely used Martini coarse-grained force field, and offers a system-agnostic suite of tools to parametrize molecules of any size, existing in any environment.
Christopher Brasnett, Maximilian Fidlin, Thilo Duve et al.· Journal of Chemical Informat...· 1 citation· ⚡1
It is found that the MIC10 proteins Mic10, Mic26, and Mic27 strongly recruit cardiolipin at conserved positive loop motifs, driving oligomerization of these subunits and resulting in the stabilization of curvature in model membranes.
C. Brown, T. Wassenaar, Z. Freyberg et al.· Science Advances· 0 citations
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