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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

S. Murta/

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2 papers indexed here

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Aug 2026

Pre-clinical evaluation of (2E,5E)-2,5-bis(isoquinolin-5-ylmethylene)-cyclopentanone as a promising leishmanicidal agent.

Leishmaniasis is a neglected tropical disease whose current treatments present several limitations. In this context, the search for new antileishmanial agents remains highly relevant. The aim of this study was to investigate the safety and therapeutic potential of (2E,5E)-2,5-bis(isoquinolin-5-ylmethylene)cyclopentanon...

Isabela Cristina Soares Martins, T. T. Santos, C. Queiroz-Junior et al. · 0 citations
Open access 2026

Furanocarboxamide Derivative Against Congenital Toxoplasmosis: Synthesis, Bioactivity, ADME Profile and in silico Insights

Overall, this work establishes compound 1 as a promising hit for congenital toxoplasmosis and malaria, providing a clear roadmap for future hit-to-lead optimization to overcome its current pharmacokinetic limitations.

J. O. Carvalho, Ana Paula C. Procópio, M. P. O. Almeida et al. · 0 citations

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