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S. Srikrishna

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Open access Aug 2026

Design, synthesis, and evaluation of pyrano[3,2-c]coumarin derivatives for simultaneous targeting of amyloid-β42 and acetylcholinesterase in transgenic AD model of Drosophila

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder involving amyloid-β (Aβ) aggregation, cholinergic dysfunction, oxidative stress, mitochondrial impairment, and progressive neuronal loss. Consequently, the development of multi-target-directed ligands (MTDLs) capable of modulating multiple patholog...

Saurabh Sharma, Shalini Sharma, Vaishali Raghuvanshi et al. · 0 citations
Aug 2026

UPLC-ESI-MS based lipidomics revealed novel biomarkers in insulin receptor knockdown induced type 2 diabetes model of Drosophila

T2D like model was established by inducing insulin resistance through knockdown of the insulin receptor in brain insulin-producing cells using the dilp2-Gal4>UAS-InRRNAisystem, which resulted in significant metabolic dysregulation, including elevated glucose, trehalose, and triacylglyceride levels, along with increased...

Prabhat Kumar, Z. Fatima, Pradeep Kumar et al. · 0 citations

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