Circulating glucagon levels are elevated in patients with diabetes and obesity and contribute to hyperglycemia. The mechanisms underlying hyperglucagonemia remain poorly understood, but expansion of pancreatic α-cell mass is thought to play an important role. Primary cilia are sensory organelles that act as signaling h...
Ganga Deshar, Mariam G. Aslanyan, Gaurav D. Diwan et al.· bioRxiv· 0 citations
These findings identify brain cilia and tanycytes as previously unrecognized sites of glucagon receptor localization and suggest that glucagon signaling at brain barrier interfaces may contribute to integrating peripheral metabolic cues with central homeostatic circuits.
C. B. Holst, O. K. Thomsen, N. Wewer Albrechtsen et al.· bioRxiv· 0 citations
Emerging evidence indicates that cell-type-specific and temporally dynamic ciliary signatures determine signalling competence and disease susceptibility, and defining these signatures and the mechanisms that regulate their plasticity could lead to new therapeutic opportunities for ciliopathies and other cilia-associate...
O. K. Thomsen, Gaia Pigino, L. B. Pedersen et al.· Nature Reviews Nephrology· 0 citations
