Emerging evidence indicates that cell-type-specific and temporally dynamic ciliary signatures determine signalling competence and disease susceptibility, and defining these signatures and the mechanisms that regulate their plasticity could lead to new therapeutic opportunities for ciliopathies and other cilia-associated diseases.
Primary cilia are microtubule-based organelles protruding from the cell surface, which are conventionally understood as passive cellular antennae that detect extracellular stimuli. However, emerging evidence redefines these microtubule-based organelles as dynamic, bidirectional hubs that integrate environmental sensing...
Huan-Tzu Hou, Yu-Ying Chao, Jie-Ning Li et al.· Journal of Biomedical Scienc...· 0 citations
The current evidence regarding the role of primary cilium in skeletal, cardiac, and smooth muscle and its potential relevance in muscle disease are examined, providing an integrated overview of cilium-dependent signaling across muscle tissues.
Esteban R. Quezada, Eugenia Morselli, S. Buvinic et al.· Biochimica et Biophysica Act...· 0 citations
It is proposed that ciliary dysfunction constitutes a convergent mechanism, perturbing neurodevelopmental signaling, neuronal polarity and synaptic maturation in a subset of ASD cases.
Arianna Boscato, Lorenzo Milesi, M. Biagioli et al.· Frontiers in Cellular Neuros...· 0 citations
The primary cilium-autophagy axis is proposed as a conceptual framework linking hemodynamic disturbance, organelle stress and vascular disease progression, and provides a basis for refining mechanistic hypotheses and potential therapeutic targets.
Xiao-Yu Fu, Wenzhe Zhou, Chen-Yu Zhang et al.· Frontiers in Cardiovascular...· 0 citations
This review bridges biophysical membrane dynamics with genetic pathology, positioning ciliary lipids not merely as structural components, but as active orchestrators of ciliary gatekeeping, cilia motility, and cilia signal transduction.
Zhen-Zhou Huang, Yuan-Yuan Liu, Han-Qi Sun et al.· Advancement of science· 0 citations
A comprehensive overview of the molecular architecture of Wnt, Notch, Hedgehog, TGF-β, and Hippo pathways, spanning ligand–receptor interactions to downstream transcriptional regulation is provided, highlighting multilayered regulatory mechanisms that fine-tune signaling outputs to ensure spatiotemporal precision in fa...
Ze Xiang, Jia-Rui Li, Yun-Yang Xu et al.· Signal Transduction and Targ...· 1 citation
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