Xylenes are ubiquitous environmental chemicals associated with central nervous system toxicity; however, their effects on cardiovascular disease are poorly understood. We tested the hypothesis that chronic m-xylene inhalation disrupts vascular homeostasis by inducing endothelial toxicity. Male C57BL/6 J mice were expos...
M. Malovichko, Samantha A. McFall, Breandon S. Taylor et al.· Toxicology and Applied Pharm...· 0 citations
It is demonstrated that repeated environmental heat stress induces coordinated neuroendocrine, vascular, immune, and metabolic adaptations characterized by activation of heat shock pathways, immune remodeling, and endothelial activation that precede cardiovascular dysfunction.
Hibah Husain, Samantha A. McFall, M. Malovichko et al.· The FASEB Journal· 0 citations
Benzene exposure is associated with increased cardiovascular disease (CVD) risk, yet the mechanisms linking benzene to vascular injury remain incompletely understood. Here, we investigated the effects of benzene and its reactive metabolite trans,trans-muconaldehyde (MA) on endothelial activation and leukocyte recruitme...
Samantha A. McFall, M. Malovichko, N. Wickramasinghe et al.· Toxicological Sciences· 0 citations
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