Samantha A. W. Tan

JNJ-42153605, a mGluR2 PAM, potentiates levetiracetam treatments of TBI to mitigate subsequent tau aggregation in a larval zebrafish model

Traumatic brain injury (TBI) has long-term consequences that include chronic traumatic encephalopathy (CTE) and an elevated risk for Alzheimer's disease (AD). These dementias ultimately manifest as tauopathies but may begin with acute neuronal dysfunction including post-traumatic seizures. Provocative evidence suggests...