Advances in genetically engineered and humanized mouse models for dissecting sepsis mechanisms and therapeutic response.
Progress in mouse genetics, CRISPR/Cas-based genome editing, conditional alleles, and next-generation humanized platforms has expanded the toolkit for functional interrogation of host pathways that shape sepsis outcomes, and can link genotype-to-phenotype mechanisms with biomarker-informed therapeutic testing.
B. Abbas, Arshad Abbas, Iqbal Nawaz Khan et al.
· Clinical Immunology · 0 citations