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Author

Sang Seo

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Sep 2026

Integrated morphological, multi-omics, and functional profiling reveals microglial plasticity driven by AD risk genes

It is shown that depletion of these AD risk genes disrupts baseline morpho-transcriptomic coupling and fundamentally alters microglial phagocytic capacity, revealing how AD GWAS genes may drive microglia into dysfunctional states characterized by altered morphology, distinct multi-omic signatures, and impaired function...

Ying-Jie Zhang, Ai Zhang, Sang Seo et al. · 0 citations

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