Sankha Bhattacharya

Targeted Colorectal Cancer Therapy Using Cabozantinib-Loaded PLGA Nanoparticles: Formulation, Cytotoxicity, and Molecular Docking Analysis.

The present study represents improved Cabozantinib delivery via Cabozantinib-loaded poly(lactic-co-glycolic acid) nanoparticles, prepared by solvent evaporation. Nanoparticles had a size of 249.5 ± 12.9 nm, a polydispersity index of 0.18, a zeta potential of +2.61 mV, and an encapsulation efficiency of 19% w/w, reflect...

Hyaluronic Acid-Polyethylene Glycol-Polycaprolactone Nanocarriers: Accurate Targeting and Multimodal Treatment for Aggressive Cancers

Polymeric nanoparticle platforms for ibrutinib delivery: tackling solubility, CYP3A4-mediated metabolism, and resistance to facilitate BTK-targeted therapy in solid tumours.

Because of its poor aqueous solubility, low oral bioavailability, extensive cytochrome P450 3A4 (CYP3A4)-mediated metabolism, and acquired resistance, ibrutinib, a first-in-class covalent Bruton's tyrosine kinase (BTK) inhibitor, has shown limited efficacy in solid tumors despite revolutionizing the treatment of B-cell...

Formulation and Evaluation of Etoposide-loaded Dextran polymeric nanoparticles fabricated with Hyaluronic acid for the treatment of colorectal cancer using network pharmacology, in-silico, in-vitro, and in-vivo approaches.

Etoposide (ETP), a Biopharmaceutics Classification System class IV drug with poor aqueous solubility, demonstrates limited therapeutic efficacy against colorectal cancer (CRC) because of inferior absorption and off-target effects. To deliver drugs specifically to cancer cells that overexpress CD44, this study developed...

Nilotinib Tartrate Encapsulated Polycaprolactone Polymeric Nanoparticle Fabricated With Lactoferrin for the Treatment of Colorectal Cancer: In-Silico and In-Vitro Investigation