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Author

Sarah J. Lincoln

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Open access Aug 2026

Brain multiomic profiling identifies tau-related transcriptomic dysregulation in Alzheimer’s disease

A hypothetical model of dynamic brain gene expression changes that track with progressive Alzheimer’s disease proteostasis is proposed and found that a beneficial brain biochemical state of higher total tau and lower phospho-Tau is associated with increased levels of synaptic, DNA damage/repair, nucleic acid metabolism...

Stephanie R. Oatman, Zachary S. Quicksall, Xue Wang et al. · 0 citations
Open access Jul 2026

Targeted proteomics of postmortem human brain reveals neurobiologic heterogeneity in Alzheimer’s disease using NULISA technology

Proteomic differences in synapse integrity, tau post-translational modification, and ubiquitination associated with age at symptomatic onset and corticolimbic distribution of tangle pathology are observed.

S. R. Dunlop, Sarah J. Lincoln, Zhongwei Peng et al. · 0 citations

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