J-domain proteins (JDPs) direct Hsp70 functions through a conserved J-domain that engages and activates Hsp70. JDPs support proteostasis and are linked to development and disease, yet how they are regulated remains unclear. Here, we identify a conserved tyrosine motif outside the canonical four-helix J-domain core, as...
Narasimharaju Kalidindi, A Leder, Guillaume Mas et al.· Communications Biology· 0 citations
The archive contains the processed ¹⁵N CEST profiles of WT Im7 recorded at 600, 800 and 1200 MHz at 10 °C and at 800 MHz at 15 and 20 °C, the ¹⁵N TROSY-CPMG profiles recorded at 600 and 800 MHz at 10 °C, and the ChemEx experiment, method and parameter files together with the shell scripts that launched every fit report...
Ved Prakash Tiwari, Laetitia Rožić, Sebastian Hiller· Zenodo (CERN European Organi...· 0 citations
The archive contains the processed ¹⁵N CEST profiles of WT Im7 recorded at 600, 800 and 1200 MHz at 10 °C and at 800 MHz at 15 and 20 °C, the ¹⁵N TROSY-CPMG profiles recorded at 600 and 800 MHz at 10 °C, and the ChemEx experiment, method and parameter files together with the shell scripts that launched every fit report...
Ved Prakash Tiwari, Laetitia Rožić, Sebastian Hiller· Zenodo (CERN European Organi...· 0 citations
A high-throughput assay to identify small molecules that specifically inhibit a protein of interest in its nascent-chain form in its nascent-chain form is presented, providing a robust platform for larger-scale screening campaigns.
P. Fischer, Sebastian Hiller· bioRxiv· 0 citations
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