Author

Sébastien Levesque

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Open access Jul 2026

Non-genotoxic transplantation and in vivo selection through epitope editing

Epitope editing of KIT enables antibody-based, non-genotoxic conditioning that selectively enriches therapeutic BCL11A-edited haematopoietic stem/progenitor cells, supports durable engraftment, preserves clonal diversity and enhances induction of fetal haemoglobin, a therapeutic approach for conditions such as sickle c...

G. Casirati, Andrea Cosentino, Marta Freschi et al. · Nature · 0 citations

#gene editing Open access Aug 2026

Analysing long-read CRISPR experiments with CRISPRLungo.

This work presents CRISPRLungo, a computational pipeline specifically designed for long-read amplicon sequencing of gene edited samples that incorporates unique molecular identifier-based error correction and statistical filtering to distinguish true editing events from background noise, enabling robust detection of sm...

Gue-Ho Hwang, Benjamin Vyshedskiy, Timothy M. Barry et al. · Nature Biomedical Engineerin... · 0 citations