Author

Selma Sinan

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One-Pot Isothermal Linear Ampliﬁcation and Cas12a-Based Nucleic Acid Detection

CATNAP (Cas trans -nuclease detection of ampliﬁed products), a method that integrates isothermal linear DNA ampliﬁcation with Cas12a detection in a single reaction, bridges the sensitivity gap in CRISPR diagnostics while maintaining simplicity, making accurate disease detection more accessible in resource-limited setti...

Selma Sinan, Remy M. Kooistra, Karunya Rajaraman et al. · 0 citations

Open access Sep 2025

Structural basis for target discrimination and activation by Cas13d

The mechanisms of nuclease activation are explored by solving seven ternary cryo-electron mi-croscopy structures of wild-type Cas13d in complex with matched and mismatched targets and an active site loop in the HEPN domains that regulates substrate accessibility is identified.

Chia-Wei Chou, Selma Sinan, Hung-Che Kuo et al. · bioRxiv · 0 citations