A conserved tyrosine motif encodes a structural vulnerability controlling stability and activity across J-domain proteins
J-domain proteins (JDPs) direct Hsp70 functions through a conserved J-domain that engages and activates Hsp70. JDPs support proteostasis and are linked to development and disease, yet how they are regulated remains unclear. Here, we identify a conserved tyrosine motif outside the canonical four-helix J-domain core, as...
Narasimharaju Kalidindi, A Leder, Guillaume Mas et al.
· Communications Biology · 0 citations