Targeting HPV16 E5 and E6 through gene-silencing approaches: mechanisms, preclinical evidence, and therapeutic perspectives
Cervical cancer, a significant global health challenge, is strongly associated with persistent infection with high-risk human papillomavirus (HPV), particularly HPV-16. The viral oncoproteins E5 and E6 are critical to HPV-mediated carcinogenesis, as they promote cell proliferation, immune evasion, apoptosis resistance,...
Zahra Zenderuh Ravanlo, Sepideh Gholami, Sanaz Baghban Rahimi et al.
· Virology Journal · 0 citations