Author

Shai Kaluski-Kopatch

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#protein folding Open access Oct 2026

The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1

Acquiring new cellular states entails metabolic reprogramming driven by changes in the expression of cytosolic and mitochondrial metabolic enzymes. Most mitochondrial proteins are synthesized in the cytosol and imported into the mitochondria in a linear form, after which they are folded by a network of mitochondrial ch...

Shani Gabbay, Hila Ben-David, Shatha S. Alassam et al. · Philosophical Transactions o... · 0 citations

#protein folding Open access Sep 2026

HSPD1 promotes neuroblastoma by augmenting MYCN expression

It is shown that HSPD1 depletion in MYCN-amplified NB cells led to reduced mitochondrial translation, MYCN expression, and tumorigenesis in vitro and in vivo and establishes HSPD1 as a promising target for the treatment of MYCN-amplified NB.

Shatha S. Alassam, Dinesh Babu Manikandan, Hila Ben-David et al. · bioRxiv · 0 citations