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Author

Shan-Long Li

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Open access Sep 2026

A unified intermediate-resolution framework for modeling biomolecular condensates at near-cellular complexity

Biomolecular condensates, formed through phase separation of multivalent biomolecules, are central to cellular organization and function. Here, we present a unified, physics-based intermediate-resolution framework for efficient and quantitative simulation of biomolecular phase separation at near-cellular complexity. Th...

Shan-Long Li, Jessica Fong Ng, Jian-Han Chen · 0 citations
#protein folding Open access Sep 2026

Intermediate-Resolution Modeling of Dynamic DNAs and Their Phase Separation

An intermediate-resolution model for condensates of DNAs (iConDNA) that can capture key local and long-range structural features of dynamic DNAs and simulate their spontaneous phase transitions is introduced, providing a suitable tool to study DNA homotypic phase separation in biological and engineering applications.

Jessica Fong Ng, Shan-Long Li, Jian-Han Chen · 0 citations
Open access Aug 2026

Antibiotic condensates activate magnesium signaling to drive drug tolerance

These findings establish antibiotic-driven phase separation as a previously unrecognized mechanism to encode cellular signaling and identify antibiotic condensates as a distinct functional unit underlying drug tolerance.

Yuefeng Ma, Wen Yu, E. Moon et al. · 0 citations

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