RNA-Binding Proteins MCPIP3 and IGF2BP3 Antagonize Lung Cancer Metastasis by Reversibly Regulating METAP2 Expression via mRNA Stability
It is revealed that the RBPs MCPIP3 (monocyte chemotactic protein-induced protein 3) and IGF2BP3 (insulin-like growth factor 2 mRNA-binding protein 3) negatively and positively regulate lung cancer cell metastasis, respectively, by antagonistically regulating METAP2 (methionine aminopeptidase 2) mRNA stability and expr...