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Shishir P. S. Chundawat

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Open access Oct 2026

Accelerating Depolymerization of Poly(ethylene terephthalate) Using Chemically Modified Cutinase and Ionic Liquids

Enzymatic depolymerization of poly(ethylene terephthalate) [PET] has shown great promise as a biocatalytic route for closing the loop on PET plastic recycling. However, there is often a trade-off between the stability of hydrolytic enzymes and the activity of the enzyme toward PET in aqueous environments near the pol...

Jake H. Nicholson, Antonio DeChellis, Annika N. Dennis et al. · 0 citations
Open access Jul 2026

Chemical Rescue Serves as a Predictive Proxy for Glycosynthase Activity on Glycosidic Bonds via a Shared Glycosyl Oxocarbenium Transition State

It is demonstrated that chemical rescue—the azide-mediated restoration of hydrolytic activity in nucleophile-deficient mutants—serves as a predictive, high-throughput proxy for glycosynthase activity as well as a structural and thermodynamic rationale for using CR to select for transition-state-stabilizing mutations.

Mohit Kumar, C. Bandi, Sri Vidya Vyjayanthi Tallavajhula et al. · 0 citations

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