Shunpei Iwamoto

From Folding Reagents to Catalysts: Spatially Organized Diselenide−Cyclodextrins Enable Catalytic Oxidative Protein Folding

Oxidative folding, involving disulfide (SS) bond formation and isomerization, is essential for the maturation of many secreted and membrane proteins. Although numerous small-molecule mimics of protein disulfide isomerase, a key enzyme that catalyzes oxidative folding, have been developed, most require superstoichiome...