Author

Simon I. R. Lane

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Open access Oct 2026

Linking centromere stretch to SAC signaling in mammalian oocytes with insights from modified kinetochore model

The spindle assembly checkpoint (SAC) monitors kinetochore-microtubule interactions to ensure accurate chromosome segregation. In mitosis, investigation of its silencing at anaphase centers on whether attachment or tension is the key signal, while in meiosis for mammalian oocytes it remains unclear whether centromere...

Y. Yun, Simon I. R. Lane, Zi-Yang Guo et al. · Communications Biology · 0 citations

#protein folding Open access Sep 2026

Droplet Microfluidic Hydrogen/Deuterium Exchange for Investigating Protein Dynamics with Millisecond Precision

Hydrogen/Deuterium eXchange (HDX) methods for studying protein dynamics would benefit from millisecond-scale incubations to probe intrinsically disordered proteins, highly dynamic regions, and conformation changes. Here, we investigate droplet microfluidics for rapid mixing to trigger D2O labeling, uniform incubation...

Dietmar Hammerschmid, Jakub Sýs, A. Bailey et al. · Analytical Chemistry · 1 citation