Author

Simone Giovannuzzi

3 papers indexed here

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Open access Sep 2026

Multitargeted Anticancer Activities: Cathepsin B–Carbonic Anhydrase IX/XII Inhibitors Show Enhanced Cytotoxicity Against Lung Adenocarcinoma Cells

The multi‐target inhibition of two significant cancer drug targets, cathepsin B and human carbonic anhydrase (hCA) isoforms IX and XII has been explored. The exclusive synthesis of single isomeric structure of final compounds despite two possibilities, in vitro biological studies, in silico molecular docking, DFT and A...

Lalit Vats, Manishita Rani, Kiran Siwach et al. · Archiv der Pharmazie · 0 citations

Open access Sep 2026

From Identification to Enzymatic Activity Profiling: Comprehensive Characterization of BloCAβ, a Probiotic β‐Carbonic Anhydrase From Bifidobacterium longum

The microbiota comprises communities of microorganisms that establish complex relationships with the host and play key roles in physiology, metabolism, and immunity. Increasing evidence highlights microbiota alterations in several diseases, particularly those driven by oxidative stress‐induced inflammation. Thus, ident...

Simone Giovannuzzi, Andrea Ammara, Simone Carradori et al. · Archiv der Pharmazie · 0 citations

#protein folding Open access Sep 2026

Harnessing coumarin privilege to achieve potency and selectivity: hypoxia-targeted alkyl coumarin-tethered phenyl quinazolinones as dual hCA IX/HSP90α inhibitors with chemosensitizing activity

A series of alkyl coumarin-tethered phenyl quinazolinones were rationally designed and synthesized as hypoxia-targeted dual hCA IX/HSP90α inhibitors, exhibiting potent, highly selective inhibition of hCA IX (in the nanomolar range), while displaying negligible activity against the off-target isoforms hCA I and II.

Amal S. Elgohary, Mervat H. El-Hamamsy, N. Sharafeldin et al. · RSC Advances · 0 citations