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Author

Songtao Dong

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Aug 2026

Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis.

This work combined site-specific chemical modification of sup-tRNAs with cargo-tailored pulmonary lipid nanoparticle (LNP) engineering to overcome barriers and restore cystic fibrosis transmembrane conductance regulator (CFTR) expression and function.

Jin-Gan Chen, Mu-Ye Zhou, Songtao Dong et al. · 1 citation

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